Compound

Property

Canagliflozin

NSC679207

NSC727709

NSC231775

TCM21610

TCM_Piperenol_A

Human Intestinal Absorption^a

+

+

+

-

+

+

P-glycoprotein Substrate^b

+

-

-

+

+

+

P-glycoprotein Inhibitor I^c

-

-

-

+

-

-

P-glycoprotein Inhibitor II^c

-

-

-

-

+

-

Renal Organic Cation Transporter^c

-

-

-

-

-

-

Blood-Brain Barrier^d

+

+

+

+

-

-

CYP450 2C9 Substrate^b

-

-

-

-

-

-

CYP450 2D6 Substrate^b

-

-

-

-

-

-

CYP450 3A4 Substrate^b

-

+

-

-

-

-

CYP450 1A2 Inhibitor^c

-

-

+

-

-

-

CYP450 2C9 Inhibitor^c

-

-

-

-

-

-

CYP450 2D6 Inhibitor^c

-

-

-

-

-

-

CYP450 2C19 Inhibitor^c

-

-

+

-

-

-

CYP450 3A4 Inhibitor^c

-

-

-

-

-

-

CYP450 Inhibitory Promiscuity

high

low

low

low

low

low

hERG inhibition I^c

-

-

-

-

-

-

hERG inhibition II^c

-

-

-

-

+

-

Ames test^e

-

-

+

-

-

-

Carcinogenicity^f

-

-

-

+

-

-