First author (year of publication)	Study design	Country of study	Study size/comparison		Patient characteristics	Glyburide group requiring insulin (n)	Dose of glyburide	Dose of insulin	Duration of study	Loss to follow up
First author (year of publication)	Study design	Country of study	Glyburide (n)	Insulin (n)	Patient characteristics	Glyburide group requiring insulin (n)	Dose of glyburide	Dose of insulin	Duration of study	Loss to follow up
Langer et al. 2000 [1]	Randomised controlled trials	Texas, United States	201	203	404 GDM women between 18 and 40 years old	8	9 ± 6 mg/day	85 ± 48 units/day	Not stated	undeclared
Bertini et al. 2005 [2]	Randomised controlled trials	Joinville SC, Brazil	24	27	70 GDM women	5	5 - 20 mg/day	0.7 - 0.9 units/kg	9 months	undeclared
Anjalakshi et al. 2006 [3]	Randomised controlled trials	Chennai, India	10	13	26 GDM women	0	0.625 mg and dose titrated once a week	0.1 units/kg and increased weekly	Not stated	Greater than 10%
Silva et al. 2007 [4]	Randomised controlled trials	Joinville SC, Brazil	32	36	68 GDM women, minimum 18 years old	6	5 - 20 mg/day	0.7 - 0.9 units/kg	1 year and 5 months	Not significant
Ogunyemi et al. 2007 [5]	Randomised controlled trials	Los Angeles, United States	48	49	97 GDM women	3	5 mg	60 units	3 years	Less than 10%
Lain et al. 2009 [6]	Randomised controlled trials	Pittsburgh, United States	41	41	99 GDM women	1	8 ± 6.7 mg/day	51.3 ± 33.4 units/day	3 years	Greater than 10%
Mukhopadhyay et al. 2012 [7]	Randomised controlled trials	Kolkata, India	30	30	60 GDM women	0	2.5 mg and increased weekly to a maximum dose of 20 mg/day	0.7 units/kg three times a day and increased when necessary	1 year	undeclared
Anjali et al. 2013 [8]	Randomised controlled trials	New Delhi, India	32	32	64 GDM women	2	5 ± 1.9 mg/day to a maximum dose of 20 mg/day	33.8 ± 22.9 units/day to a maximum dose of 84 units/day	1 year	Less than 10%