Patient Cohort

P value for comparisons with general population

All Patients N = 121

All Migraine N = 83

All Migraine w/out aura N = 80

General Population

All patients

Migraine patients

Migraine w/out aura patients

ApoE (CVD risk)

<0.0001

<0.0001

<0.0001

Low

82 (67.8)

57 (68.7)

54 (67.5)

7342 (83.8)

<0.0001

0.0002

<0.0001

Intermediate

11 (9.1)

10 (12.1)

10 (12.5)

1424 (16.2)

0.0330

0.2984

0.3618

High

28 (23.1)

16 (19.3)

16 (20.0)

0 (0)

<0.0001

<0.0001

<0.0001

Factor II

0.6055

1.00

1.00

Detected heterozygote

2 (1.7)

2 (2.4)

2 (2.5)

810 (3.2)

0.4439

1.00

1.00

Detected homozygote

0 (0)

0 (0)

0 (0)

10 (0.04)

1.00

1.00

1.00

Not detected

119 (98.3)

81 (97.6)

78 (97.5)

24,313 (96.7)

0.4439

1.00

1.00

Factor V Leiden

0.0066

0.0004

0.0003

Detected heterozygote

9 (7.4)

7 (8.4)

7 (8.7)

1270 (5.1)

0.2325

0.1995

0.1213

Detected homozygous mutant

1 (0.8)

1 (1.2)

1 (1.3)

19 (0.08)

0.0916

0.0638

0.0616

Not detected

111 (91.7)

75 (90.4)

72 (90.0)

23,847 (94.9)

0.1192

0.0757

0.0676

MTHFR

0.0063

0.0026

0.0029

Detected heterozygote

26 (21.5)

18 (21.7)

18 (22.5)

5522 (22.0)

0.8988

0.9508

0.9086

Detected homozygous mutant

18 (14.9)

14 (16.9)

13 (16.3)

3127 (12.4)

0.4181

0.2226

0.3028

Intermediate sensitivity

1 (0.8)

1 (1.2)

1 (1.2)

0 (0)

0.0048

0.0033

0.0032

Not detected

76 (62.8)

50 (60.2)

48 (60.0)

16,488 (65.6)

0.5204

0.3056

0.2932