| Patient Cohort | P value for comparisons with general population | ||||||
| All Patients N = 121 | All Migraine N = 83 | All Migraine w/out aura N = 80 | General Population | All patients | Migraine patients | Migraine w/out aura patients | |
| CYP4502C9 | 0.6266 | 0.4845 | 0.3539 | ||||
| high | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1.00 | 1.00 | 1.00 |
| intermediate | 40 (33.1) | 26 (31.3) | 23 (28.8) | 3933 (33.2) | 0.9641 | 0.7265 | 0.4058 |
| normal | 76 (62.8) | 53 (63.9) | 53 (66.2) | 7593 (64.1) | 0.7690 | 0.9634 | 0.6892 |
| poor | 5 (4.1) | 4 (4.8) | 4 (5.0) | 320 (2.7) | 0.3874 | 0.2897 | 0.1726 |
| CYP3A4 | <0.0001 | <0.0001 | <0.0001 | ||||
| high | 5 (4.1) | 4 (4.8) | 4 (5.0) | 0 (0) | <0.0001 | <0.0001 | <0.0001 |
| intermediate | 12 (9.9) | 8 (9.6) | 7 (8.8) | 776 (7.4) | 0.3030 | 0.4479 | 0.6571 |
| normal | 104 (86.0) | 71 (85.5) | 69 (86.2) | 9600 (92.1) | 0.0138 | 0.0292 | 0.0562 |
| poor | 0 (0) | 0 (0) | 0 (0) | 52 (0.5) | 1.00 | 1.00 | 1.00 |
| CYP3A5 | <0.0001 | <0.0001 | <0.0001 | ||||
| high | 6 (5.0) | 5 (6.0) | 5 (6.3) | 0 (0) | <0.0001 | <0.0001 | <0.0001 |
| intermediate | 12 (9.9) | 8 (9.6) | 7 (8.7) | 1373 (13.2) | 0.02829 | 0.3343 | 0.252 |
| normal | 103 (851) | 70 (84.3) | 68 (85.0) | 68 (0.7) | <0.0001 | <0.0001 | <0.0001 |
| poor | 0 (0) | 0 (0) | 0 (0) | 8938 (86.1) | |||
| CYP2D6 | <0.0001 | <0.0001 | <0.0001 | ||||
| high | 11 (9.2) | 7 (8.6) | 7 (9.0) | 4587 (38.9) | <0.0001 | <0.0001 | <0.0001 |
| intermediate | 17 (14.3) | 15 (18.5) | 14 (18.0) | 5601 (47.5) | <0.0001 | <0.0001 | <0.0001 |
| normal | 85 (71.4) | 53 (65.4) | 52 (66.7) | 0 (0) | <0.0001 | <0.0001 | <0.0001 |
| poor | 6 (5.0) | 6 (7.4) | 5 (6.4) | 1604 (13.6) | <0.0001 | <0.0001 | <0.0001 |
| CYPC19 | 0.1971 | 0.2962 | 0.3473 | ||||
| high | 36 (29.8) | 26 (31.7) | 26 (32.9) | 3702 (31.2) | 0.733 | 0.97979 | 0.8019 |
| intermediate | 32 (26.4) | 21 (25.6) | 20 (25.3) | 2326 (19.6) | 0.0595 | 0.1927 | 0.2257 |
| normal | 47 (38.8) | 32 (39.0) | 31 (38.8) | 4854 (40.9) | 0.6465 | 0.6644 | 0.6962 |
| poor | 6 (5.0) | 3 (3.7) | 3 (3.8) | 985 (8.3) | 0.1842 | 0.1244 | 0.1408 |
| VKORC1* | 0.0375 | 0.0254 | 0.0323 | ||||
| high | 10 (8.3) | 6 (7.3) | 6 (7.6) | 1625 (14.1) | 0.0693 | 0.0772 | 0.0961 |
| intermediate | 72 (60.0) | 52 (63.4) | 50 (63.3) | 5644 (49.1) | 0.0172 | 0.0096 | 0.0118 |
| low | 38 (31.7) | 24 (29.3) | 23 (29.1) | 4232 (36.8) | 0.2462 | 0.1588 | 0.1581 |