Mean

Start (pre-CAI)

3 months

6 months

12 months Final

% improvement start-end

p-value*

MF in 12 h

7.0 ± 0.6

4.1 ± 0.4

3.0 ± 0.1

3.0 ± 0.6

56.4%

0.001*

AIMS

16 ± 0.6

5.8 ± 0.7

6.2 ± 1.0

4.2 ± 0.5

74.0%

0.001*

% in S & E

60%

70%

70%

70%

16.7%

<0.001*

NPI

16 ± 0.6

7.8 ± 0.8

6.2 ± 1.0

8 ± 0.6

49.9%

0.001*

NMSS

77.8 ± 5.2

64 ± 4.4

63 ± 2.2

63 ± 1.6

18.8%

0.017*

HADS

A

9.0 ± 0.6

7.0 ± 1.3

7.0 ± 0.6

7.0 ± 0.6

21.7%

0.016*

D

17.3 ± 2.4

16.2 ± 8

14.2 ± 1.2

12.9 ± 0.5

32.1%

0.001*