Mean

Start (pre-CAI)

3 months

6 months

12 months Final

% improvement start-end

p-value

MF in 12 h

5.5 ± 0.5

1.0 ± 0.5

0.9 ± 0.4

2.0 ± 0.6

63.9%

0.001*

AIMS

14 ± 0.6

7 ± 0.6

4 ± 1.4

2 ± 6.3

85.7%

<0.001*

% in S & E

70%

90%

90%

90%

28.6%

<0.001*

NPI

8.0 ± 0.6

4.2 ± 0.7

2.0 ± 0.6

2.0 ± 0.6

74.9%

0.001*

NMSS

42.2 ± 2.2

22 ± 2.3

20.7 ± 4.3

16 ± 1.4

62.0%

0.002*

HADS

A

8.0 ± 0.6

6.0 ± 0.6

6.0 ± 0.6

4.0 ± 0.6

24.1%

0.008*

D

15 ± 0.9

13 ± 0.6

12.8 ± 1.0

9.2 ± 1.0

39.9%

0.001*