Group A (n = 9)

Start

3 months

6 months

9 months

12 months

Levodopa (mg)

723 ± 15

722 ± 11

722 ± 6

723 ± 6

730 ± 8

Dopaminergic agonists

Pramipexol, no. patients (mg)

9 (2.6 ± 0.2)

3 (2.1 ± 0.2)

-

-

-

Pen-delivered apomorphine

mg/day

66 ± 3

32 ± 4

18 ± 2

5 ± 2

-

no. boluses

8

2

2

1

Apomorphine in perfusion

ml/h

0.4 ± 0.2

0.8 ± 0.2

0.8 ± 0.2

1 ± 0.1

1.2 ± 0.2

12 hours/day

12

11.8 ± 0.2

11.8 ± 0.2

11.6 ± 0.4

11.4 ± 0.6

no. boluses (bolus volume)

2 (0.4 ml)

3 (0.3 ml)

3 (0.3 ml)

2 (0.3 ml)

2 (0.3 ml)

Group B (n = 6)

Start

3 months

6 months

9 months

12 months

Levodopa (mg)

920 ± 12

923 ± 10

933 ± 5

910 ± 20

915 ± 16

Dopaminergic agonists:

Rotigotine no. patients (mg)

6 (12 ± 2)

3 (6 ± 2)

1 (4 ± 2)

1 (4 ± 2)

1 (4 ± 2)

Pramipexole no. patients (mg)

3 (2.1 ± 0.0)

-

-

-

-

Pen-delivered apomorphine

mg/day

64 ± 4

42 ± 6

12 ± 2

5

4

no. boluses

5

3

2

1

1

Apomorphine in perfusion

ml/h

0.4 ± 0.2

0.8 ± 0.2

0.9 ± 0.2

0.9 ± 0.1

0.9 ± 0.1

12 hours/day

12

11.7± 0.2

11.5 ± 0.1

11.1 ± 0.2

11.1 ± 0.2

no. boluses

(bolus volume)

3

(0.4ml)

2

(0.3ml)

2

(0.3ml)

2

(0.3ml)

2

(0.3ml)