Cell types

Potential Mechanism

Effect to autophagy

References (first author, year)

CAM

NAADP-Lysosome-Ca2+

Positive

Zhang, 2010

CAM

Autophagic flux

Positive

Xu, 2011

Astrocytes

NAADP/TPCs, LC3-II, Beclin-1

Positive

Pereria, 2011

VEC, VSMC

NAADP/TRPML1/TPCs

Positive

Li, 2013

MGP

LC3-II

Positive

Xiong, 2013

CAM

Autophagic flux

Positive

Zhang, 2014

CAM

Dynein ATPase

Positive

Xu, 2014

B cells

Blimp1, Beclin-1/p62

Positive

Yuan, 2014

293T cells

NAADP/TRPML1, LRRK2/CaMKK/AMPK

Negative

Gomez-Suaga, 2012

CLL cells

Beclin-1, Bcl-2, Autophagic flux

Negative

Bologna, 2013

Hela cells, ESC

NAADP/TPC2/Ca2+ signaling, lysosomal pH

Negative

Lu, 2013

ESC

NAADP/TPC2/Ca2+ Signaling

Negative

Lu, 2013

IHP

Autophagic flux

Negative

Gomez-Puerto, 2016