|
| Yes | No | Do not know or not done | Our patient |
| (1) Are there previous conclusive reports on this reaction? | +1 | 0 | 0 | 0 |
| (2) Did the adverse events appear after the suspected drug was given? | +2 | −1 | 0 | +2 |
| (3) Did the adverse reaction improve when the drug was discontinued or a specific antagonist was given? | +1 | 0 | 0 | +1 |
| (4) Did the adverse reaction appear when the drug was readministered? | +2 | −1 | 0 | +2 |
| (5) Are there alternative causes that could have caused the reaction? | −1 | +2 | 0 | +2 |
| (6) Did the reaction reappear when a placebo was given? | −1 | +1 | 0 | 0 |
| (7) Was the drug detected in any body fluid in toxic concentrations? | +1 | 0 | 0 | 0 |
| (8) Was the reaction more severe when the dose was increased, or less severe when the dose was increased? | +1 | 0 | 0 | 0 |
| (9) Did the patient have a similar reaction to the same or similar drugs in any previous exposure? | +1 | 0 | 0 | 0 |
| (10) Was the adverse event confirmed by any objective evidence? | +1 | 0 | 0 | +1 |
| Totals |
|
|
| 8 |