| Hypertension Genetically triggered thoracic aortic disease | |
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| Marfan syndrome Bicuspid aortic valve Loeys-Dietz syndrome Vascular Ehlers-Danlos syndrome |
| Congenital diseases/syndromes | |
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| Coarctation of the aorta Turner syndrome Tetralogy of Fallot |
| Atherosclerosis | |
|
| Penetrating atherosclerotic ulcer |
| Trauma, blunt, or iatrogenic | |
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| Catheter/stent Intraaortic balloon pump Aortic/vascular surgery Motor vehicle accident Coronary artery bypass surgery/aortic valve replacement |
| Cocaine use | Catecholamine induced acute hypertension |
| Inflammatory/infectious diseases | |
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| Giant cell arteritis Takayasu arteritis Behet’s disease (immune mediated small-vessel systemic vasculitis) Aortitis Syphilis |
| Pregnancy | Hypertension precipitates proximal aortic dissection and aortic rupture, commonly occurs during 3rd trimester or during the first stage of labour |