| Patients took SSRI or SNRI n = 16 | Patients don’t took SSRI or SNRI n = 39 | Mann-Whitney U | z | p | |
| Age (years) | 45.75 ± 13.27 | 45.28 ± 11.44 | 290.500 | −0.399 | 0.690 |
| Hight (m) | 162.08 ± 7.84 | 161.42 ± 7.35 | 263.000 | −0.909 | 0.363 |
| Weight (kg) | 60.76 ± 8.08 | 60.75 ± 11.91 | 250.000 | −0.556 | 0.579 |
| BMI | 23.28 ± 3.76 | 23.22 ± 3.44 | 268.000 | −0.192 | 0.848 |
| CGI-S | 3.88 ± 0.81 | 3.90 ± 0.79 | 304.500 | −0.158 | 0.875 |
| SDS | 51.93 ± 12.62 | 51.53 ± 10.40 | 243.000 | −0.261 | 0.794 |
| HDR-S | 18.94 ± 5.32 | 17.92 ± 5.70 | 268.500 | −0.808 | 0.419 |
| Triptophan (μM) | 56.98 ± 13.00 | 59.65 ± 13.72 | 298.000 | −0.259 | 0.795 |
| L-5-Hydroxytryptophan (nM) | 8.13 ± 5.08 | 8.60 ± 4.27 | 68.500 | −0.198 | 0.843 |
| Serotonin (nM) | 215.13 ± 249.99 | 311.18 ± 275.84 | 112.000 | −1.246 | 0.213 |
| Kynurenine (nM) | 1856.63 ± 596.73 | 1603.71 ± 727.67 | 226.500 | −1.584 | 0.113 |
| 5-Hydroxytryptophol (nM) | 0.00 ± 0.00 | 12.60 ± 11.60 | - | - | - |
| Tryptophol (nM) | 24.73 ± 12.85 | 2.42 ± 3.57 | 0.000 | −2.236 | <0.05 |
| 5-Hydroxyindoleacetic acid (nM) | 39.05 ± 47.94 | 32.60 ± 31.35 | 272.000 | −0.741 | 0.459 |
| Indole-3-acetic acid (nM) | 2212.73 ± 1454.54 | 1736.09 ± 1275.02 | 234.000 | −1.445 | 0.148 |
| Anthranilic acid (nM) | 15.84 ± 22.44 | 9.60 ± 7.95 | 14.000 | −0.183 | 0.855 |
| Kynurenic acid (nM) | 39.45 ± 18.07 | 44.08 ± 35.54 | 284.000 | −0.519 | 0.604 |
| Quinaldic acid (nM) | 9.42 ± 5.76 | 6.85 ± 3.70 | 64.500 | −0.935 | 0.350 |
| 3-Indolebutyric acid (nM) | 19.27 ± 10.72 | 17.81 ± 17.16 | 216.000 | −1.428 | 0.153 |
| 3-Hydroxykynurenine (nM) | 19.90 ± 11.97 | 22.05 ± 12.75 | 272.000 | −0.741 | 0.459 |
| 3-hydroxyanthranilic acid (nM) | 24.45 ± 16.26 | 24.96 ± 18.99 | 183.000 | −0.512 | 0.609 |
| Xanthurenic acid (nM) | 13.05 ± 5.77 | 14.52 ± 11.25 | 271.000 | −0.276 | 0.782 |
| Melatonin (nM) | 20.65 ± 31.35 | 5.38 ± 8.91 | 5.000 | −0.866 | 0.386 |
| Quinolinic acid (positive) (nM) | 379.50 ± 270.30 | 376.81 ± 531.39 | 246.000 | −0.969 | 0.333 |
| 5-HTRP/TRP | 0.13 ± 0.08 | 0.16 ± 0.09 | 55.000 | −0.962 | 0.336 |
| serotonin/TRP | 3.70 ± 4.19 | 5.22 ± 4.39 | 110.000 | −1.302 | 0.193 |
| 5-HIAA/TRP | 0.70 ± 0.78 | 0.65 ± 0.84 | 255.000 | −1.056 | 0.291 |
| KYN/TRP | 33.57 ± 11.58 | 27.73 ± 13.35 | 205.000 | −1.983 | <0.05 |