Diagnosis

MDD n = 38

BD n = 17

significant

differences

Sample name

young men n = 7

a

young women n = 18

b

old men n = 3

c

old women n = 10

d

young men n = 2

a

young women n = 10

b

old men n = 3

c

old women n = 2

d

Age (years)

36.00 ± 9.256

40.00 ± 7.004

60.00 ± 14.73

59.40 ± 7.306

40.50 ± 0.707

39.40 ± 8.140

58.33 ± 4.619

51.00 ± 0.000

*1

Height (m)

1.72 ± 0.07

1.59 ± 0.06

1.64 ± 0.10

1.59 ± 0.05

1.63 ± 0.00

1.58 ± 0.04

1.73 ± 0.04

1.56 ± 0.01

*2

Weight (kg)

74.41 ± 12.86

55.92 ± 7.670

58.95 ± 16.05

54.52 ± 8.389

73.00 ± 9.899

59.34 ± 2.215

74.17 ± 7.522

60.30 ± 3.677

*3

BMI

24.97 ± 3.998

22.31 ± 4.051

22.51 ± 2.772

21.58 ± 2.982

27.48 ± 3.726

23.69 ± 1.371

25.02 ± 3.572

24.77 ± 1.062

-

CGI-S

4.429 ± 0.535

3.667 ± 0.907

4.667 ± 0.577

3.700 ± 0.483

4.000 ± 0.000

4.100 ± 0.738

3.000 ± 1.000

4.000 ± 0.000

*4

SDS

62.43 ± 6.754

45.00 ± 13.31

58.00 ± 1.414

52.22 ± 6.399

63.00 ± 4.243

51.56 ± 7.986

44.33 ± 8.387

55.00 ± 7.071

*5

HDR-S

21.29 ± 3.817

16.94 ± 5.150

29.67 ± 5.033

18.30 ± 4.398

18.00 ± 0.000

17.70 ± 5.012

11.00 ± 2.000

15.00 ± 2.828

*6

ID2: Tryptophan (μM)

64.09 ± 13.77

58.48 ± 10.40

59.11 ± 2.026

51.24 ± 11.01

57.71 ± 2.006

61.68 ± 16.96

78.50 ± 10.30

39.66 ± 11.91

*7

ID3: L-5-Hydroxytryptophan (nM)

11.26 ± 3.447

9.191 ± 2.942

1.1800000

8.106 ± 6.660

-

7.598 ± 0.886

1.2260000

-

-

ID4: Serotonin (nM)

325.6 ± 351.4

267.6 ± 204.4

120.3 ± 96.01

160.2 ± 145.2

302.0 ± 45.28

459.7 ± 402.5

250.3 ± 184.6

200.5 ± 128.0

-

ID5: Kynurenine (nM)

2506.5 ± 1042.9

1653.0 ± 510.16

1014.2 ± 418.25

1666.4 ± 534.60

1119.0 ± 161.08

1389.8 ± 342.36

2426.2 ± 628.86

914.89 ± 73.22

*8

ID6: 5-Hydroxytryptophol (nM)

-

10.50

25.11

2.20

-

-

-

-

-

ID7: Tryptophol (nM)

2.2950000

12.00 ± 18.10

-

11.99 ± 11.18

-

-

-

-

-

ID8: 5-Hydroxyindoleacetic acid (nM)

28.04 ± 22.07

35.00 ± 28.99

22.82 ± 28.11

48.68 ± 58.22

10.62 ± 6.362

17.01 ± 13.09

29.83 ± 7.324

116.83 ± 27.63

*9

ID9 :Indole-3-acetic acid (nM)

2631.3 ± 1666.0

2068.4 ± 1525.8

583.0 ± 266.4

2412.5 ± 1026.1

852.8 ± 418.1

1500.7 ± 959.3

835.1 ± 217.5

1184.4 ± 1195.2

-

ID10: Anthranilic acid (nM)

5.61

14.29 ± 11.76

-

13.89 ± 21.11

-

11.59

-

-

-

ID11: Kynurenic acid (nM)

67.07 ± 39.75

32.09 ± 15.37

26.47 ± 12.76

36.57 ± 14.38

24.87 ± 14.39

41.91 ± 25.76

113.43 ± 60.29

24.55 ± 18.43

*10

ID12: Quinaldic acid (nM)

10.14 ± 7.55

7.46 ± 3.27

-

7.81 ± 3.96

-

9.97 ± 4.84

1.99 ± 0.86

-

-

ID13: 3-Indolebutyric acid (nM)

18.93 ± 12.54

18.45 ± 11.93

2.92 ± 4.04

25.62 ± 20.27

4.39 ± 0.49

19.94 ± 18.23

2.95 ± 0.00

5.72 ± 1.80

-

ID14: 3-Hydroxykynurenine (nM)

19.03 ± 14.17

20.55 ± 11.06

29.96 ± 8.09

13.98 ± 5.98

28.66 ± 0.35

29.00 ± 16.64

25.91 ± 9.04

10.21 ± 13.06

-

ID15: 3-hydroxyanthranilic acid (nM)

27.37 ± 11.08

28.12 ± 21.21

-

26.85 ± 14.18

0.52 ± 0.00

19.91 ± 21.48

18.15 ± 14.70

-

-

ID16: Xanthurenic acid (nM)

19.50 ± 11.06

10.12 ± 6.17

11.88 ± 1.91

13.05 ± 5.79

7.65 ± 7.65

16.48 ± 13.72

30.84 ± 13.55

9.75

*11

ID17: Melatonin (nM)

0.17

6.61 ± 8.26

-

25.85 ± 36.24

-

-

-

-

-

ID19: Quinolinic acid (positive) (nM)

776.1 ± 1091.6

404.6 ± 277.7

168.5 ± 5.9

334.1 ± 303.9

168.2 ± 2.8

259.2 ± 200.1

227.7 ± 96.9

134.3 ± 13.3

-