Diagnosis | MDD n = 38 | BD n = 17 | significant differences | ||||||
Sample name | young men n = 7 a | young women n = 18 b | old men n = 3 c | old women n = 10 d | young men n = 2 a | young women n = 10 b | old men n = 3 c | old women n = 2 d | |
Age (years) | 36.00 ± 9.256 | 40.00 ± 7.004 | 60.00 ± 14.73 | 59.40 ± 7.306 | 40.50 ± 0.707 | 39.40 ± 8.140 | 58.33 ± 4.619 | 51.00 ± 0.000 | *1 |
Height (m) | 1.72 ± 0.07 | 1.59 ± 0.06 | 1.64 ± 0.10 | 1.59 ± 0.05 | 1.63 ± 0.00 | 1.58 ± 0.04 | 1.73 ± 0.04 | 1.56 ± 0.01 | *2 |
Weight (kg) | 74.41 ± 12.86 | 55.92 ± 7.670 | 58.95 ± 16.05 | 54.52 ± 8.389 | 73.00 ± 9.899 | 59.34 ± 2.215 | 74.17 ± 7.522 | 60.30 ± 3.677 | *3 |
BMI | 24.97 ± 3.998 | 22.31 ± 4.051 | 22.51 ± 2.772 | 21.58 ± 2.982 | 27.48 ± 3.726 | 23.69 ± 1.371 | 25.02 ± 3.572 | 24.77 ± 1.062 | - |
CGI-S | 4.429 ± 0.535 | 3.667 ± 0.907 | 4.667 ± 0.577 | 3.700 ± 0.483 | 4.000 ± 0.000 | 4.100 ± 0.738 | 3.000 ± 1.000 | 4.000 ± 0.000 | *4 |
SDS | 62.43 ± 6.754 | 45.00 ± 13.31 | 58.00 ± 1.414 | 52.22 ± 6.399 | 63.00 ± 4.243 | 51.56 ± 7.986 | 44.33 ± 8.387 | 55.00 ± 7.071 | *5 |
HDR-S | 21.29 ± 3.817 | 16.94 ± 5.150 | 29.67 ± 5.033 | 18.30 ± 4.398 | 18.00 ± 0.000 | 17.70 ± 5.012 | 11.00 ± 2.000 | 15.00 ± 2.828 | *6 |
ID2: Tryptophan (μM) | 64.09 ± 13.77 | 58.48 ± 10.40 | 59.11 ± 2.026 | 51.24 ± 11.01 | 57.71 ± 2.006 | 61.68 ± 16.96 | 78.50 ± 10.30 | 39.66 ± 11.91 | *7 |
ID3: L-5-Hydroxytryptophan (nM) | 11.26 ± 3.447 | 9.191 ± 2.942 | 1.1800000 | 8.106 ± 6.660 | - | 7.598 ± 0.886 | 1.2260000 | - | - |
ID4: Serotonin (nM) | 325.6 ± 351.4 | 267.6 ± 204.4 | 120.3 ± 96.01 | 160.2 ± 145.2 | 302.0 ± 45.28 | 459.7 ± 402.5 | 250.3 ± 184.6 | 200.5 ± 128.0 | - |
ID5: Kynurenine (nM) | 2506.5 ± 1042.9 | 1653.0 ± 510.16 | 1014.2 ± 418.25 | 1666.4 ± 534.60 | 1119.0 ± 161.08 | 1389.8 ± 342.36 | 2426.2 ± 628.86 | 914.89 ± 73.22 | *8 |
ID6: 5-Hydroxytryptophol (nM) | - | 10.50 | 25.11 | 2.20 | - | - | - | - | - |
ID7: Tryptophol (nM) | 2.2950000 | 12.00 ± 18.10 | - | 11.99 ± 11.18 | - | - | - | - | - |
ID8: 5-Hydroxyindoleacetic acid (nM) | 28.04 ± 22.07 | 35.00 ± 28.99 | 22.82 ± 28.11 | 48.68 ± 58.22 | 10.62 ± 6.362 | 17.01 ± 13.09 | 29.83 ± 7.324 | 116.83 ± 27.63 | *9 |
ID9 :Indole-3-acetic acid (nM) | 2631.3 ± 1666.0 | 2068.4 ± 1525.8 | 583.0 ± 266.4 | 2412.5 ± 1026.1 | 852.8 ± 418.1 | 1500.7 ± 959.3 | 835.1 ± 217.5 | 1184.4 ± 1195.2 | - |
ID10: Anthranilic acid (nM) | 5.61 | 14.29 ± 11.76 | - | 13.89 ± 21.11 | - | 11.59 | - | - | - |
ID11: Kynurenic acid (nM) | 67.07 ± 39.75 | 32.09 ± 15.37 | 26.47 ± 12.76 | 36.57 ± 14.38 | 24.87 ± 14.39 | 41.91 ± 25.76 | 113.43 ± 60.29 | 24.55 ± 18.43 | *10 |
ID12: Quinaldic acid (nM) | 10.14 ± 7.55 | 7.46 ± 3.27 | - | 7.81 ± 3.96 | - | 9.97 ± 4.84 | 1.99 ± 0.86 | - | - |
ID13: 3-Indolebutyric acid (nM) | 18.93 ± 12.54 | 18.45 ± 11.93 | 2.92 ± 4.04 | 25.62 ± 20.27 | 4.39 ± 0.49 | 19.94 ± 18.23 | 2.95 ± 0.00 | 5.72 ± 1.80 | - |
ID14: 3-Hydroxykynurenine (nM) | 19.03 ± 14.17 | 20.55 ± 11.06 | 29.96 ± 8.09 | 13.98 ± 5.98 | 28.66 ± 0.35 | 29.00 ± 16.64 | 25.91 ± 9.04 | 10.21 ± 13.06 | - |
ID15: 3-hydroxyanthranilic acid (nM) | 27.37 ± 11.08 | 28.12 ± 21.21 | - | 26.85 ± 14.18 | 0.52 ± 0.00 | 19.91 ± 21.48 | 18.15 ± 14.70 | - | - |
ID16: Xanthurenic acid (nM) | 19.50 ± 11.06 | 10.12 ± 6.17 | 11.88 ± 1.91 | 13.05 ± 5.79 | 7.65 ± 7.65 | 16.48 ± 13.72 | 30.84 ± 13.55 | 9.75 | *11 |
ID17: Melatonin (nM) | 0.17 | 6.61 ± 8.26 | - | 25.85 ± 36.24 | - | - | - | - | - |
ID19: Quinolinic acid (positive) (nM) | 776.1 ± 1091.6 | 404.6 ± 277.7 | 168.5 ± 5.9 | 334.1 ± 303.9 | 168.2 ± 2.8 | 259.2 ± 200.1 | 227.7 ± 96.9 | 134.3 ± 13.3 | - |