Diagnosis

BD n = 17

significant

differences

Sample name

young men n = 2

a

young women n = 10

b

old men n = 3

c

old women n = 2

d

Age (years)

40.50 ± 0.707

39.40 ± 8.140

58.33 ± 4.619

51.00 ± 0.000

b vs c: p < 0.01

b vs d: p < 0.01

Height (m)

1.63 ± 0.00

1.58 ± 0.04

1.73 ± 0.04

1.56 ± 0.01

b vs c: p < 0.01

c vs d: p < 0.01

Weight (kg)

73.00 ± 9.899

59.34 ± 2.215

74.17 ± 7.522

60.30 ± 3.677

a vs b: p < 0.05

b vs c: p < 0.01

c vs d: p < 0.05

BMI

27.48 ± 3.726

23.69 ± 1.371

25.02 ± 3.572

24.77 ± 1.062

-

CGI-S

4.000 ± 0.000

4.100 ± 0.738

3.000 ± 1.000

4.000 ± 0.000

-

SDS

63.00 ± 4.243

51.56 ± 7.986

44.33 ± 8.387

55.00 ± 7.071

-

HDR-S

18.00 ± 0.000

17.70 ± 5.012

11.00 ± 2.000

15.00 ± 2.828

-

ID2: Triptophan (μM)

57.71 ± 2.006

61.68 ± 16.96

78.50 ± 10.30

39.66 ± 11.91

-

ID3: L-5-Hydroxytryptophan (nM)

-

7.598 ± 0.886

1.2260000

-

-

ID4: Serotonin (nM)

302.0 ± 45.28

459.7 ± 402.5

250.3 ± 184.6

200.5 ± 128.0

-

ID5: Kynurenine (nM)

1119.0 ± 161.08

1389.8 ± 342.36

2426.2 ± 628.86

914.89 ± 73.22

a vs c: p < 0.05

b vs c: p < 0.01

c vs d: p < 0.01

ID6: 5-Hydroxytryptophol (nM)

-

-

-

-

-

ID7: Tryptophol (nM)

-

-

-

-

-

ID8: 5-Hydroxyindoleacetic acid (nM)

10.62 ± 6.362

17.01 ± 13.09

29.83 ± 7.324

116.83 ± 27.63

a vs d: p < 0.01

b vs d: p < 0.01

c vs d: p < 0.01

ID9 :Indole-3-acetic acid (nM)

852.8 ± 418.1

1500.7 ± 959.3

835.1 ± 217.5

1184.4 ± 1195.2

-

ID10: Anthranilic acid (nM)

-

11.59

-

-

ID11: Kynurenic acid (nM)

24.87 ± 14.39

41.91 ± 25.76

113.43 ± 60.29

24.55 ± 18.43

b vs c: p < 0.05

ID12: Quinaldic acid (nM)

-

9.97 ± 4.84

1.99 ± 0.86

-

-

ID13: 3-Indolebutyric acid (nM)

4.39 ± 0.49

19.94 ± 18.23

2.95 ± 0.00

5.72 ± 1.80

-

ID14: 3-Hydroxykynurenine (nM)

28.66 ± 0.35

29.00 ± 16.64

25.91 ± 9.04

10.21 ± 13.06

-

ID15: 3-hydroxyanthranilic acid (nM)

0.52 ± 0.00

19.91 ± 21.48

18.15 ± 14.70

-

-

ID16: Xanthurenic acid (nM)

7.65 ± 7.65

16.48 ± 13.72

30.84 ± 13.55

9.75

-

ID17: Melatonin (nM)

-

-

-

-

-

ID19: Quinolinic acid (positive) (nM)

168.2 ± 2.8

259.2 ± 200.1

227.7 ± 96.9

134.3 ± 13.3

-