Diagnosis

MDD n = 38

significant

differences

Sample name

young men n = 7

a

young women n = 18

b

old men n = 3

c

old women n = 10

d

Age (years)

36.00 ± 9.256

40.00 ± 7.004

60.00 ± 14.73

59.40 ± 7.306

a vs c: p < 0.01

a vs d: p < 0.01

b vs c: p < 0.01

b vs d: p < 0.01

b vs d: p < 0.01

Height (m)

1.72 ± 0.07

1.59 ± 0.06

1.64 ± 0.10

1.59 ± 0.05

a vs b: p < 0.01

a vs d: p < 0.01

Weight (kg)

74.41 ± 12.86

55.92 ± 7.670

58.95 ± 16.05

54.52 ± 8.389

a vs b: p < 0.01

a vs d: p < 0.01

BMI

24.97 ± 3.998

22.31 ± 4.051

22.51 ± 2.772

21.58 ± 2.982

-

CGI-S

4.429 ± 0.535

3.667 ± 0.907

4.667 ± 0.577

3.700 ± 0.483

-

SDS

62.43 ± 6.754

45.00 ± 13.31

58.00 ± 1.414

52.22 ± 6.399

a vs b: p < 0.01

HDR-S

21.29 ± 3.817

16.94 ± 5.150

29.67 ± 5.033

18.30 ± 4.398

b vs c: p < 0.01

c vs d: p < 0.01

ID2: Triptophan (μM)

64.09 ± 13.77

58.48 ± 10.40

59.11 ± 2.026

51.24 ± 11.01

-

ID3: L-5-Hydroxytryptophan (nM)

11.26 ± 3.447

9.191 ± 2.942

1.1800000

8.106 ± 6.660

-

ID4: Serotonin (nM)

325.6 ± 351.4

267.6 ± 204.4

120.3 ± 96.01

160.2 ± 145.2

-

ID5: Kynurenine (nM)

2506.5 ± 1042.9

1653.0 ± 510.16

1014.2 ± 418.25

1666.4 ± 534.60

a vs b: p < 0.05

a vs c: p < 0.05

ID6: 5-Hydroxytryptophol (nM)

-

10.50

25.11

2.20

-

ID7: Tryptophol (nM)

2.2950000

12.00 ± 18.10

-

11.99 ± 11.18

-

ID8: 5-Hydroxyindoleacetic acid (nM)

28.04 ± 22.07

35.00 ± 28.99

22.82 ± 28.11

48.68 ± 58.22

-

ID9 :Indole-3-acetic acid (nM)

2631.3 ± 1666.0

2068.4 ± 1525.8

583.0 ± 266.4

2412.5 ± 1026.1

-

ID10: Anthranilic acid (nM)

5.61

14.29 ± 11.76

-

13.89 ± 21.11

-

ID11: Kynurenic acid (nM)

67.07 ± 39.75

32.09 ± 15.37

26.47 ± 12.76

36.57 ± 14.38

-

ID12: Quinaldic acid (nM)

10.14 ± 7.55

7.46 ± 3.27

-

7.81 ± 3.96

-

ID13: 3-Indolebutyric acid (nM)

18.93 ± 12.54

18.45 ± 11.93

2.92 ± 4.04

25.62 ± 20.27

-

ID14: 3-Hydroxykynurenine (nM)

19.03 ± 14.17

20.55 ± 11.06

29.96 ± 8.09

13.98 ± 5.98

-

ID15: 3-hydroxyanthranilic acid (nM)

27.37 ± 11.08

28.12 ± 21.21

-

26.85 ± 14.18

-

ID16: Xanthurenic acid (nM)

19.50 ± 11.06

10.12 ± 6.17

11.88 ± 1.91

13.05 ± 5.79

-

ID17: Melatonin (nM)

0.17

6.61 ± 8.26

-

25.85 ± 36.24

-

ID19: Quinolinic acid (positive) (nM)

776.1 ± 1091.6

404.6 ± 277.7

168.5 ± 5.9

334.1 ± 303.9

-