Symptoms

Number and percent of patients

with improvement

with no change

with worsening

p-values*

Bradykinesia

226 (46.7%)

242 (50.0%)

16 (3.3%)

<0.001

Rigidity

186 (38.4%)

279 (57.6%)

19 (3.9%)

<0.001

Tremor

243 (50.3%)

221 (45.8%)

19 (3.9%)

<0.001

Postural instability

161 (33.3%)

302 (62.5%)

20 (4.1%)

<0.001

Daytime sleepiness

137 (28.3%)

290 (59.9%)

57 (11.8%)

<0.001

Fatigue

212 (43.9%)

229 (47.4%)

42 (8.7%)

<0.001

Mood disturbances

148 (30.6%)

287 (59.3%)

49 (10.1%)

<0.001

Psychosis

21 (4.4%)

442 (91.7%)

19 (3.9%)

<0.001

Memory disturbances

92 (19.2%)

338 (70.4%)

50 (10.4%)

<0.001

Social difficulties

120 (26.8%)

298 (66.5%)

30 (6.7%)

<0.001

Sexual dysfunction

55 (11.5%)

397 (82.7%)

28 (5.8%)

<0.001

Urinary problems

69 (14.5%)

365 (76.8%)

41 (8.6%)

<0.001

Olfactory disturbances

41 (8.5%)

423 (88.1%)

16 (3.3%)

<0.001

Pain

137 (28.4%)

306 (63.5%)

39 (8.1%)

<0.001