Symptoms | Number and percent of patients |
| ||
with improvement | with no change | with worsening | p-values* | |
Bradykinesia | 226 (46.7%) | 242 (50.0%) | 16 (3.3%) | <0.001 |
Rigidity | 186 (38.4%) | 279 (57.6%) | 19 (3.9%) | <0.001 |
Tremor | 243 (50.3%) | 221 (45.8%) | 19 (3.9%) | <0.001 |
Postural instability | 161 (33.3%) | 302 (62.5%) | 20 (4.1%) | <0.001 |
Daytime sleepiness | 137 (28.3%) | 290 (59.9%) | 57 (11.8%) | <0.001 |
Fatigue | 212 (43.9%) | 229 (47.4%) | 42 (8.7%) | <0.001 |
Mood disturbances | 148 (30.6%) | 287 (59.3%) | 49 (10.1%) | <0.001 |
Psychosis | 21 (4.4%) | 442 (91.7%) | 19 (3.9%) | <0.001 |
Memory disturbances | 92 (19.2%) | 338 (70.4%) | 50 (10.4%) | <0.001 |
Social difficulties | 120 (26.8%) | 298 (66.5%) | 30 (6.7%) | <0.001 |
Sexual dysfunction | 55 (11.5%) | 397 (82.7%) | 28 (5.8%) | <0.001 |
Urinary problems | 69 (14.5%) | 365 (76.8%) | 41 (8.6%) | <0.001 |
Olfactory disturbances | 41 (8.5%) | 423 (88.1%) | 16 (3.3%) | <0.001 |
Pain | 137 (28.4%) | 306 (63.5%) | 39 (8.1%) | <0.001 |