CGI-S scores at

baseline (Visit 1)

CGI-S scores at

12-week follow-up (Visit 2)

p-values

Bradykinesia

2.2 ± 1.2

1.6 ± 1.1

<0.001

Rigidity

1.8 ± 1.0

1.3 ± 0.9

<0.001

Tremor

2.0 ± 1.3

1.3 ± 1.1

<0.001

Postural instability

1.5 ± 1.4

1.1 ± 1.3

<0.001

Daytime sleepiness

1.9 ± 1.5

1.6 ± 1.4

<0.001

Fatigue

2.7 ± 1.4

2.2 ± 1.3

<0.001

Mood disturbances

2.0 ± 1.5

1.6 ± 1.4

<0.001

Psychosis

0.2 ± 0.6

0.2 ± 0.7

0.950

Memory disturbances

2.7 ± 1.5

1.5 ± 1.4

0.001

Social difficulties

2.8 ± 1.6

1.4 ± 1.5

<0.001

Sexual dysfunction

1.0 ± 1.5

0.9 ± 1.3

0.006

Urinary problems

1.5 ± 1.5

1.4 ± 1.5

0.024

Olfactory disturbances

3.9 ± 1.7

4.0 ± 1.6

0.001

Pain

1.1 ± 1.7

1.0 ± 1.5

<0.001