| Models of pain | Aminoadamantane derivatives and their mode of administration | |||
| Hemantane, 20 mg/kg | Amantadine, 20 mg/kg | |||
| Intraperitoneally | Orally | Intraperitoneally | Orally | |
| Acute thermal pain | + | + | + | 0 |
| Persistent pain produced by acute inflammation | + | + | + | 0 |
| Formalin pain | Hemantane, 20 mg/kg intraperitoneally | Amantadine, 20 mg/kg intraperitoneally | ||
| The acute early phase of formalin pain | 0 | + | ||
| The late tonic phase of formalin pain | + | 0 | ||