|
|
Time after the formalin injection, min |
Average score |
||||||||
| 20 min |
25 min |
30 min |
35 min |
40 min |
45 min |
50 min |
55 min |
60 min |
||
| Control, saline |
3.0 (2.0 ÷ 3.0) |
2.5 (2.0 ÷ 3.0) |
2.0 (2.0 ÷ 2.0) |
2.0 (2.0 ÷ 2.0) |
2.0 (2.0 ÷ 2.0) |
2.0 (2.0 ÷ 2.0) |
2.0 (2.0 ÷ 2.0) |
2.0 (1.0 ÷ 2.0) |
2.0 (0.5 ÷ 2.0) |
18.5 (17.5 ÷ 19.5) |
| Hemantane, 20 mg/kg |
1.0 (0.0 ÷ 2.0)* |
2.0 (2.0 ÷ 2.0) |
2.0 (2.0 ÷ 2.0) |
2.0 (2.0 ÷ 2.0) |
2.0 (2.0 ÷ 2.0) |
1.5 (1.0 ÷ 2.0) |
2.0 (1.0 ÷ 2.0) |
1.0 (1.0 ÷ 2.0) |
0.5 (0.0 ÷ 2.0) |
13.5 (12.0 ÷ 16.0)* |
| Amantadine, 20 mg/kg |
1.5 (1.0 ÷ 2.0) |
2.0 (1.5 ÷ 2.0) |
2.0 (2.0 ÷ 2.5) |
2.0 (1.0 ÷ 2.0) |
2.0 (1.5 ÷ 2.0) |
1.0 (1.0 ÷ 2.0) |
1.5 (1.0 ÷ 2.0) |
1.5 (1.0 ÷ 2.0) |
2.0 (1.0 ÷ 2.0) |
15.5 (12.5 ÷ 17.5) |
| Diclofenac sodium, 10 mg/kg |
1.0 (1.0 ÷ 1.0)* |
2.0 (1.0 ÷ 2.0)* |
2.0 (2.0 ÷ 2.0) |
2.0 (2.0 ÷ 2.0) |
1.5 (1.0 ÷ 2.0) |
1.0 (1.0 ÷ 2.0) |
1.0 (1.0 ÷ 2.0) |
1.0 (0.0 ÷ 2.0) |
1.0 (0.0 ÷ 2.0) |
13.0 (8.0 ÷ 17.0)* |