MP formulation No.

PLGA type

Co-grinding time (min)

TDC (%)

EDC (%)

LE (%)

Particle size (μm)

1

PLGA7505

10

9.1

9.4 ± 0.0

103.2 ± 0.4

32.9 ± 18.5

2

PLGA7510

10

9.1

9.1 ± 0.0

99.7 ± 0.0

30.4 ± 19.1

3

PLGA7505

10

16.7

17.1 ± 0.1

102.2 ± 0.5

32.3 ± 19.6

4

PLGA7510

10

16.7

17.1 ± 0.2

102.3 ± 1.0

29.2 ± 20.4

5

PLGA7505

60

9.1

9.5 ± 0.0

104.2 ± 0.5

20.5 ± 10.1

6

PLGA7505

60

16.7

17.3 ± 0.1

103.8 ± 0.6

25.2 ± 16.6