Time (min)

% Release of Drug in Water Medium

% Release of Drug in Phosphate Medium

Pure Gliclazide

Gliclazide + Aerosil,

PMs (1:3)

Gliclazide + Aerosil,

SDs (1:3)

Pure Gliclazide

Gliclazide + Aerosil,

PMs (1:3)

Gliclazide + Aerosil,

SDs (1:3)

5

0.96 ± 0.06

11.4 ± 0.06

38.05 ± 0.07

8.10 ± 0.08^ΨΨΨ

21.79 ± 0.06^†††

40.99 ± 0.07***

15

3.65 ± 0.06

19.92 ± 0.07

39.98 ± 0.09

12.55 ± 0.09^ΨΨΨ

29.45 ± 0.08^†††

42.16 ± 0.09***

30

4.19 ± 0.07

24.13 ± .09

41.15 ± 0.09

26.32 ± 0.10^ΨΨΨ

29.57 ± 0.08^†††

42.53 ± 0.10***

60

8.10 ± 0.07

26.86 ± 0.09

41.90 ± 0.10

29.51 ± 0.11^ΨΨΨ

29.68 ± 0.09^†††

42.68 ± 0.10**

90

9.48 ± 0.08

28.44 ± 0.10

42.58 ± 0.11

30.77 ± 0.11^ΨΨΨ

29.70 ± 0.10^††

42.72 ± 0.11

120

11.2 0 ± 0.10

29.20 ± 0.10

42.65 ± 0.12

31.02 ± 0.12^ΨΨΨ

29.70 ± 0.11^†

42.75 ± 0.12

240

14.60 ± 0.11

29.25 ± 0.11

42.72 ± 0.13

31.69 ± 0.12^ΨΨΨ

29.77 ± 0.12^†

43.04 ± 0.12