Method

Time

(min)

Pure Gliclazide

(% release)

% Release of Drug from SD’s (Gliclazide: Aerosil) in Water

3:1

2:1

1:1

1:2

1:3

Solvent method

5

0.96 ± 0.06

15.85 ± 0.05^†††

20.39 ± 0.06^†††

30.97 ± 0.06^†††

33.85 ± 0.07^†††

38.05 ± 0.07^†††

15

3.65 ± 0.06

18.21 ± 0.06^†††

24.71 ± 0.08^†††

35.71 ± 0.08^†††

39.89 ± 0.08^†††

39.98 ± 0.09^†††

30

4.19 ± 0.07

20.13 ± 0.07^†††

27.60 ± 0.08^†††

37.90 ± 0.08^†††

41.05 ± 0.08^†††

41.15 ± 0.09^†††

60

8.10 ± 0.07

22.31 ± 0.08^†††

29.93 ± 0.09^†††

39.31 ± 0.09^†††

41.86 ± 0.10^†††

41.90 ± 0.10^†††

90

9.48 ± 0.08

23.55 ± 0.10^†††

31.29 ± 0.10^†††

39.64 ± 0.10^†††

42.50 ± 0.10^†††

42.58 ± 0.11^†††

120

11.20 ± 0.10

24.57 ± 0.10^†††

31.69 ± 0.11^†††

39.68 ± 0.11^†††

42.62 ± 0.11^†††

42.65 ± 0.12^†††

240

14.65 ± 0.11

28.24 ± 0.11^†††

34.43 ± 0.11^†††

39.72 ± 0.12^†††

42.68 ± 0.12^†††

42.72 ± 0.13^†††