Formulation | Drug dissolved (μg/ml) | |||||
5 min | 15 min | 30 min | 60 min | 90 min | 120 min | |
FF | 8.8 ± 0.4 | 12.6 ± 0.6 | 13.3 ± 0.1 | 15.0 ± 0.1 | 15.0 ± 0.1 | 15.0 ± 0.3 |
SDF1 | 21.1 ± 0.1* | 23.9 ± 0.1* | 24.9 ± 0.1* | 26.8 ± 0.3* | 27.8 ± 0.3* | 29.7 ± 0.2* |
SDF2 | 16.3 ± 0.1* | 18.2 ± 0.2* | 19.2 ± 0.1* | 21.1 ± 0.2* | 21.0 ± 0.1* | 22.0 ± 0.1* |
SDF3 | 16.3 ± 0.2* | 19.2 ± 0.2* | 19.2 ± 0.1* | 21.1 ± 0.2* | 21.1 ± 0.3* | 21.9 ± 0.3* |
SDF4 | 10.3 ± 0.3* | 12.9 ± 0.3* | 14.1 ± 0.6* | 18.2 ± 0.3* | 20.7 ± 0.2* | 23.3 ± 0.3* |
SDF5 | 14.2 ± 0.2* | 14.6 ± 0.3* | 15.1 ± 0.2* | 17.3 ± 0.3* | 23.3 ± 0.2* | 24.8 ± 0.1* |
SDF6 | 15.9 ± 0.1* | 18.0 ± 0.2* | 18.1 ± 0.1* | 23.2 ± 0.2* | 23.8 ± 0.1* | 26.4 ± 0.2* |
SDF7 | 29.6 ± 0.1*Ϯ↑ | 30.7 ± 0.2*Ϯ↑ | 34.8 ± 0.2*Ϯ↑ | 35.9 ± 0.1*Ϯ↑ | 38.0 ± 0.2*Ϯ↑ | 38.3 ± 0.5*Ϯ↑ |