| Treatment | Doses | Immobility time |
| Deionized water | 0.1 ml/mice | 106.20 ± 17.890 |
| Imipramine Hydrochloride | 30 mg/kg | 18.50 ± 3.403* |
| META | 50 mg/kg | 46.25 ± 5.250* |
| META | 100 mg/kg | 41.0 ± 2.121* |
| META | 200 mg/kg | 31.80 ± 7.479* |