|
Antibiotic | GA (wks) | PNA (days) | Unit dose (mg/Kg) | Dosing interval (h) | ||||
| Current Study | BNFC | ISN guide | Current Study | BNFC | ISN guide | |||
| Ampicillin (n = 18) | ≤27 wks 28 - 32 wks
≤29 wks 30 - 32 Wks
|
<7 days 7 - 20 days 21 - 28 days 0 - 28 days 0 - 14 days >14 days | 50 (100*) 50 (100*)
|
30 (60 - 100*) 30 (60 - 100*) 30 (60 - 100*)
|
50 (100*) 50 (100*) 50 (100*) | 6 - 12 12 - 24
|
12 8 6
|
12 12 8 |
| Gentamicin (n = 15) | ≤27 wks 28 - 32 wks
≤29 wks
30 - 32 wks
|
<7 days 7 - 28 days 0 - 14 days ≥15 days 0 - 7 days ≥8 days | 2.5 (5*) 2.5 (5*)
|
5* 5*
|
2.5 2.5 2.5 2.5 | 24 - 36 - 48 18 - 24 - 36 - 48
|
36 24
|
24 - 36 18 - 24 18 12 - 18 |
| Vancomycin (n = 14) | ≤27 wks 28 - 32 wks <29 wks 29 - 32 wks ≤29 wks
30 - 32 wks
|
0 - 14 days >14 days 0 - 14 days >14 days | 10 - 15* 10 - 15*
|
15 15
|
10 - 15* 10 - 15* 10 - 15* 10 - 15* | 6 - 8 - 12 - 18 - 24 12
|
24 12
|
18 12 12 8 |
| Amikacin (n = 9) | ≤27 wks 28 - 32 wks
≤28 wks 29 - 32 wks
|
0 - 28 days 0 - 24 days 0 - 7 days ≥8 days | 7.5 (15*) 7.5 (15*)
|
7.5 (15*)
|
7.5 7.5 7.5 | 8 - 24 - 36 12 - 24 - 36
|
12 - 24
|
24 12 8 |