Groups/Parameters | Control I, n = 12 | Control II, n = 12 | Main group, = 48 D-galactoside induced aging group | |||
Control III | I | II | III | |||
Body weight, g 180 days at the beginning of the studying | 186 ± 19 | 298 ± 23x | 257 ± 18 | 277 ± 17 | 270 ± 21 | 259 ± 21 |
Relative weight, mg dry/100 mg wet weight | 31.4 ± 1.4 | 32.1 ± 1.2 | 24.4 ± 1.5** | 28.9 ± 1.4# | 28.0 ± 1.6# | 27.1 ± 1.5# |
Hexosamine mg/g wet tissue | 16.4 ± 1.4 | 18.2 ± 1.2 | 23.7 ± 2.3* | 17.8 ± 4.1# | 19.3 ± 4.3# | 21.8 ± 1.2* |
Hydroxyprolinemg/g wet tissue | 15.0 ± 0.8 | 17.2 ± 0.9x | 13.7 ± 0.8** | 15.9 ± 0.9# | 15.4 ± 1.1# | 14.8 ± 1.2* |
Total collagen, mg/g wet tissue | 112 ±10 | 129 ± 10 | 102 ± 6* | 119 ± 8# | 115 ± 8# | 111 ± 9 |
NaCl-Soluble collagen, mg/g wet tissue | 7.1 ± 1.1 | 7.7 ± 1.0 | 4.4 ± 0.8** | 6.5 ± 0.5## | 6.35 ± 0.63## | 5.97 ± 0.78# |
Acid-Soluble collagen, mg/g wet tissue | 0.12 ± 0.02 | 0.13 ± 0.03 | 0.07 ± 0.01** | 0.10 ± 0.01*# | 0.10 ± 0.01*# | 0.09 ± 0.01* |
Pepsin-Soluble collagen, mg/g wet tissue | 0.85 ± 0.08 | 0.88 ± 0.08 | 1.8 ± 0.2*** | 0.95 ± 0.10### | 1.09 ± 0.09### | 1.47 ± 0.15# |
Insoluble collagen, mg/g wet tissue | 105 ± 9 | 121 ± 9 | 97 ± 9* | 113 ± 6# | 109 ± 6 | 105 ± 7 |
NF-kB(p65) activity, o.u. at 450 nm | 0.07 ± 0.02 | 0.09 ± 0.01 | 0.21 ± 0.03 | 0.10 ± 0.02 | 0.10 ± 0.03 | 0.14 ± 0.02 |