Groups/Parameters

Control I,

n = 12

Control II,

n = 12

Main group, = 48

D-galactoside induced aging group

Control III

I

II

III

Body weight, g 180 days at the beginning of the studying

186 ± 19

298 ± 23^x

257 ± 18

277 ± 17

270 ± 21

259 ± 21

Relative weight, mg dry/100 mg wet weight

31.4 ± 1.4

32.1 ± 1.2

24.4 ± 1.5**

28.9 ± 1.4#

28.0 ± 1.6#

27.1 ± 1.5#

Hexosamine mg/g wet tissue

16.4 ± 1.4

18.2 ± 1.2

23.7 ± 2.3*

17.8 ± 4.1#

19.3 ± 4.3#

21.8 ± 1.2*

Hydroxyprolinemg/g wet tissue

15.0 ± 0.8

17.2 ± 0.9^x

13.7 ± 0.8**

15.9 ± 0.9#

15.4 ± 1.1#

14.8 ± 1.2*

Total collagen, mg/g wet tissue

112 ±10

129 ± 10

102 ± 6*

119 ± 8#

115 ± 8#

111 ± 9

NaCl-Soluble collagen, mg/g wet tissue

7.1 ± 1.1

7.7 ± 1.0

4.4 ± 0.8**

6.5 ± 0.5##

6.35 ± 0.63##

5.97 ± 0.78#

Acid-Soluble collagen, mg/g wet tissue

0.12 ± 0.02

0.13 ± 0.03

0.07 ± 0.01**

0.10 ± 0.01*#

0.10 ± 0.01*#

0.09 ± 0.01*

Pepsin-Soluble collagen, mg/g wet tissue

0.85 ± 0.08

0.88 ± 0.08

1.8 ± 0.2***

0.95 ± 0.10###

1.09 ± 0.09###

1.47 ± 0.15#

Insoluble collagen, mg/g wet tissue

105 ± 9

121 ± 9

97 ± 9*

113 ± 6#

109 ± 6

105 ± 7

NF-kB(p65) activity, o.u. at 450 nm

0.07 ± 0.02

0.09 ± 0.01

0.21 ± 0.03

0.10 ± 0.02

0.10 ± 0.03

0.14 ± 0.02