K-RAS

mutations

in the 4th exon

c. 436 G→A (p. Ala146Thr)

c. 436 G→A (p. Ala146Thr)

Wt

c. 436 G→A (p. Ala146Thr)

N-RAS

Mutations

in the 2nd, 3-d, 4th exons

Wt

Wt

B-Raf mutations

in 11th exon

Wt

B-Raf mutations

in 15th exon

Wt

Wt

Wt

PIC3CA

mutations

in the 9th, 20th exon

Wt

UGT1A1

promoter

A(TA)6TAA

MS BAT25

Wt

Wt

MS BAT26, NR21, NR24, NR 27

High level of

instability

MS D2S123, D5S346, D17S250

Wt