Question

D0

End

Mean

Mean

p-value*

Disease severity

2.26

1.11

<0.0001

Behavior/Mood

1.58

0.61

<0.0001

Sleep

0.84

0.32

0.0068

Meals

0.42

0.16

0.0439

Playing/working

1.29

0.50

0.0002

Social relationship

0.61

0.39

0.1724

Changes in habits

0.95

0.53

0.0277

Therapies

1.61

0.76

0.0003

Lost time

2.00

1.08

<0.0001

Physical exhaustion

1.11

0.61

0.0081

Usual activities

1.11

0.66

0.0286

Expenditure

2.13

1.53

0.0044

Emotional suffering

1.39

1.13

0.2011

Physical restlessness

0.58

0.29

0.0441

Family relationship

0.47

0.24

0.1040

Total

18.34

9.89

<0.0001