IgG subclass

Type of the subclass

Variants

Amino Acids at hinge region

IgG1

H and L (κ and λ) chains (conventional)

IgG1a, IgG1b

IgG1a: 19

IgG1b: 12

IgG2

Heavy chain Ab (HCAbs)

γ2a, γ2c

γ2a: 35

γ2c: 12

IgG3

Heavy chain Ab (HCAbs)

γ3

γ3: 15