Inhibitors

1'-hydroxymidazolam

4-hydroxymidazolam

V_max (nmol/min/kg)

K_m (mM)

K_i (mM)

V_max (nmol/min/kg)

K_m (mM)

K_i (mM)

CPFX

0.15 ± 0.06

14.62 ± 13.24

5.81 ± 5.48

0.15 ± 0.07

32.36 ± 16.86

9.13 ± 2.23

OBFX

0.14 ± 0.08

15.76 ± 19.4

11.68 ± 3.45

0.11 ± 0.05

29.29 ±10.45

21.11 ± 11.92

NFX

0.12 ± 0.07

5.07± 3.90

25.60 ± 12.94

0.13 ± 0.06

29.11 ± 14.01

24.11 ± 13.95

OFX

0.17 ± 0.06

43.78 ± 50.76

32.98 ± 20.40

0.15 ± 0.08

39.43 ±17.22

23.05 ± 7.24

EFX

0.14 ± 0.08

6.04 ± 6.27

34.68 ± 31.49

0.14 ± 0.09

29.88 ± 4.26

28.76 ± 14.67