Mouse models

Effects of ablation of specific adaptive immune components on C. rodentium infection


Mice lacking CD4+ T cells or TCRαβ+ T cells

A survival limit of two weeks and exhibited 100% mortality

[59] [64]

Mice lacking CD8+ T cells or TCRγδ+ T cells

Do not adversely affect survival of infection


Mice without mature B cells (μMT mice)

Cannot lessen bacterial load or clear bacterial colonization over a prolonged period

[63] [65] [66]

RAG1-deficient mice (both B and T cells are absent)

Develop chronic intestinal colonization and unable to clear infection and die after 3-4 weeks

[59] [63] [67]

IgA- and IgM- deficient mice

Develop effective immunity against a secondary challenge and play a negligible role in controlling C. rodentium infection.


Mice deficient in IgG antibodies

Lose the ability to develop protective response against secondary challenge.


IFNγ-deficient mice

Higher bacterial numbers and enhanced mucosal thickening in colons and cannot clear infection until day 28


IL-12 deficient mice

Elicit higher bacterial numbers for the first 3 weeks of infection and eventually clear infection by day 35


Mice lacking IL-22

Display systemic bacterial load and enhanced epithelial hyperplasia and mortality range up to 100% within the first two weeks of infection


Treg deficient mice (DEREG mice)

Diminished bacterial clearance, systemic dissemination of bacteria with compromised Th17 immune response accompanied by less inflammation-associated pathology


IL-10 ablated mice

Resolve infection earlier than wild-type mice with less infection associated colitis