Deductions

REF

Complete skin disinfection would “require the penetration of disinfectant throughout the whole pilosebaceous canal”

[94]

[100]

Sebum production follows a defined circadian pattern

[95] [96]

Temperature can influence the degree of drug deposition in the hair follicle.

[97]

Drug depletion in the hair follicle is a slow processes and can either go deeper by penetration into deeper tissue layers or by flowing out of the follicle with the sebum production

[98]

Penetration of substances into the follicle can be increased when massage is applied.

[99]

As much as 25% of the cutaneous bacterial population can be sequestered within the hair follicles

[101]

Bacterial biofilms have been observed in the deeper portion of the human hair follicle.

[102]

The “swab method” for bacterial culture only identifies bacterial colonies at the level of the superficial stratum corneum.

[103]

Large biofilm-like macro colonies have been observed in the deep part of the hair follicle.

[104]

Certain topicals could be detected for up to 4 days in a follicle after delivery.

[105]