No. | Amino acids change | SNP&GO Prediction | SNP&GO RI | PHD SNP Prediction | PHD RI | I-Mutant Prediction | I-Mutant RI | MUpro |
1 | C46Y | Disease | 6 | Disease | 1 | Increase | 4 | Decrease |
2 | R64W | Disease | 3 | Disease | 3 | Decrease | 7 | Decrease |
3 | W87R | Disease | 5 | Disease | 1 | Decrease | 8 | Decrease |
4 | R227H | Disease | 4 | Disease | 1 | Decrease | 7 | Decrease |
5 | I272T | Disease | 2 | Disease | 7 | Decrease | 9 | Decrease |
6 | Y291C | Disease | 6 | Disease | 8 | Decrease | 6 | Decrease |
7 | D293Y | Disease | 8 | Disease | 9 | Decrease | 1 | Decrease |
8 | R310Q | Disease | 4 | Neutral | 3 | Decrease | 8 | Decrease |
9 | R326W | Disease | 3 | Disease | 6 | Decrease | 6 | Decrease |
10 | S333C | Neutral | 7 | Disease | 2 | Decrease | 7 | Decrease |
11 | D344E | Neutral | 3 | Neutral | 3 | Increase | 0 | Decrease |
12 | T353M | Disease | 6 | Disease | 7 | Decrease | 3 | Decrease |
13 | I357T | Neutral | 1 | Disease | 4 | Decrease | 3 | Decrease |
14 | P358L | Disease | 6 | Disease | 8 | Decrease | 4 | Decrease |
15 | L360P | Disease | 7 | Disease | 9 | Decrease | 5 | Decrease |
16 | G361R | Disease | 7 | Disease | 9 | Decrease | 7 | Decrease |
17 | R376W | Neutral | 3 | Disease | 3 | Decrease | 8 | Decrease |
18 | G377R | Neutral | 0 | Disease | 6 | Decrease | 8 | Decrease |
19 | Q394R | Disease | 6 | Disease | 9 | Decrease | 6 | Decrease |