Gene name

Expression Fold Change

Effect on lung cancer

ACTG1

−66.515

Found to be upregulated in small cell lung cancers. Overexpression has been linked to higher metastatic potential in hepatocellular carcinoma. This suggests that ACTG1 is likely assisting in cancer metastasis in lung cancers [14] .

ENO1

−177.945

Found to induce tumor growth and metastasis in vivo in lung adenocarcinomas [15]

FLNA

−67.865

High expression induces resistance to gefitinib, while lowering expression restores sensitivity to gefitinib. Lower expression is also able to induce apoptosis [3] .

LARP4

25.148

Typically has a lower expression in non-small cell lung cancers including A549. Higher expression could inhibit migration and invasion [4] .

RPL19

−115.264

Lowering RPL19 levels was found to inhibit the growth of lung cancers that typically have an overexpression of RPL19. It is a proposed target for immunotherapy [16] .

RPS16

−73.909

Higher levels linked to lower survival rate in lung cancer patients [17] .

RPS27A

−88.972

Direct transcriptional target of p53 that is highly overexpressed in lung cancer. Appears to be a promising target for treatment [18] .

TM4SF1

−86.345

Upregulated in non-small cell lung cancers. Promotes cell proliferation, migration, and invasion while also inhibiting apoptosis [19] .

UBB

−84.321

Overexpression leads to a lower survival rate in lung cancer patients [20] .

YBX1

−75.424

High levels have been associated with poor prognosis in cancer patients [21] .