| Molecule | GPCR | Ion Channel | Kinase |
| Ligand | Modulator | Inhibitor | |
| Leu-Enkephalin | 0.38 | −0.05 | −0.10 |
| Molecule | Nuclear Receptor | Protease | Enzyme |
| Ligand | Inhibitor | Inhibitor | |
| Leu-Enkephalin | 0.06 | 0.59 | 0.18 |