| Compound | Spiked amount (ng/mL) | Accuracy (RE%) | Precision (CV%) | Recovery (%) | ||||||
| Intra-day (n = 5) | Inter-day (n = 15) | Intra-day (n = 5) | Inter-day (n = 15) | |||||||
| Day 1 | Day 2 | Day 3 | Total | Day 1 | Day 2 | Day 3 | Total | ( n = 3) | ||
| Plasma | ||||||||||
| Delamanid | 16 | 2.8 | 2.1 | −0.6 | 1.4 | 2.3 | 2.2 | 3.6 | 3.0 | 96.5 |
|
| 160 | 8.3 | 10.0 | 6.0 | 8.1 | 2.3 | 7.0 | 4.3 | 4.8 | 102.0 |
|
| 800 | 12.0 | −4.9 | 7.2 | 4.8 | 1.8 | 6.9 | 4.1 | 8.2 | 90.8 |
| IS | 200 | − | − | − | − | − | − | − | − | 101.4 |
| Lung homogenate | ||||||||||
| Delamanid | 30 | 11.7 | 2.9 | 0.9 | 5.1 | 5.0 | 2.3 | 1.9 | 5.6 | 93.5 |
|
| 100 | 6.8 | 0.1 | −0.6 | 2.1 | 5.1 | 1.7 | 1.1 | 4.5 | 97.8 |
|
| 800 | −5.3 | −2.9 | 0.8 | −2.5 | 3.7 | 2.3 | 1.3 | 3.6 | 100.0 |
| IS | 100 | − | − | − | − | − | − | − | − | 99.3 |