P53

MDM2

HO-1

Nrf2

control

0.176 ± 0.049

0.971 ± 0.075

1.084 ± 0.104

1.015 ± 0.077

DOX

1.175 ± 0.081^#

0.371 ± 0.096^#

0.225 ± 0.101^#

0.468 ± 0.035

GLPS (low) + DOX

0.798 ± 0.245**

0.532 ± 0.108**

0.395 ± 0.093**

0.531 ± 0.054*

GLPS (high) + DOX

0.441 ± 0.09***

0.77 ± 0.072***

0.612 ± 0.146***

0.7 ± 0.161**