| Ref. | Type of study | Assessment methods | Results and comments |
| Cohen et al., [16] . | Randomized Placebo | *VAS and **WOMAC | VAS scores higher for group undergoing treatment. There was no WOMAC difference. |
| Erhan et al., [17] . | Randomized, Placebo, Double blind | VAS and WOMAC Radiography | No significant difference demonstrated between the two groups. |
| Hammad et al., [18] . | Randomized Oral route versus topical route | VAS and WOMAC Radiografia | Skin delivery superior in improving joint stiffness. No significant differences in other aspects. |
| Onigbinde et al. [19] . | Randomized 3 groups: GS and exercise | VAS | No significant difference demonstrated between the two groups. |
| Onigbinde et al. [20] . | Randomized GS versus NSAIDs | VAS | No significant difference demonstrated between the two groups. |