Study

Methods

Subjects

Pathologies

Interventions

Outcomes

Bonci 1994

RCT

Doble-blinding

Placebo controlled

Adult patients < 16 years old.

Acute inflammatory pathologies of the middle ear.

Oral carbocysteine for a maximum of 15 days.

400 mg/day.

Subjective symptoms as hearing loss, overall assessment.

Malka 1990

RCT

Doble-blinding

Placebo controlled

Paediatric ambulatory 2 - 12 years.

Acute bronchitis.

Oral carbocysteine for 7 days. 200 mg/day and 300 mg/day in > 5 years old.

Cough, expectoration, dyspnoea.

Nakayama 1977

RCT

Doble-blinding

Placebo controlled

Paediatric ambulatory 0 - 18 years.

Acute bronchitis.

Oral carbocysteine 30 mg/kg/day for 7 days.

Overall assessment, stridor, expectoration, cough.

Zanini 1974

RCT

Doble-blinding

Placebo controlled

Paediatric hospitalization.

Acute respiratory infections.

Oral carbocysteine 100 to 400 mg/day for 5 to 9 days.

Cough, dyspnoea, temperature, general condition, appetite.