Study | Methods | Subjects | Pathologies | Interventions | Outcomes |
Bonci 1994 | RCT Doble-blinding Placebo controlled | Adult patients < 16 years old. | Acute inflammatory pathologies of the middle ear. | Oral carbocysteine for a maximum of 15 days. 400 mg/day. | Subjective symptoms as hearing loss, overall assessment. |
Malka 1990 | RCT Doble-blinding Placebo controlled | Paediatric ambulatory 2 - 12 years. | Acute bronchitis. | Oral carbocysteine for 7 days. 200 mg/day and 300 mg/day in > 5 years old. | Cough, expectoration, dyspnoea. |
Nakayama 1977 | RCT Doble-blinding Placebo controlled | Paediatric ambulatory 0 - 18 years. | Acute bronchitis. | Oral carbocysteine 30 mg/kg/day for 7 days. | Overall assessment, stridor, expectoration, cough. |
Zanini 1974 | RCT Doble-blinding Placebo controlled | Paediatric hospitalization. | Acute respiratory infections. | Oral carbocysteine 100 to 400 mg/day for 5 to 9 days. | Cough, dyspnoea, temperature, general condition, appetite. |