Healthy Subjects

Patients

p^†

N

10

36

Age, yr

53.5 ± 11.3

65.2 ± 13.2

0.01

Gender, M/F

6/4

20/16

--

BMI

30.1 ± 4.7

27.8 ± 6

NS

FVC, L

3.6 ± 0.8

3 ± 1

0.05

FVC, %

91.3 ± 10

83.1 ± 19.4

0.05

FEV₁, L

2.9 ± 0.6

2.2 ± 0.7

0.05

FEV₁, % pred

99.1 ± 12.6

85.8 ± 22.4

0.02

FEV₁/FVC, %

80.6 ± 5.4

73.8 ± 10.7

<0.05

MVV, L/min

134.4 ± 28

94.8 ± 35.4

0.01

MVV, % pred

109.6 ± 10.1

87 ± 26.2

<0.005