Overall

2011

2014

2016

p-value

No. of patients

100

40

30

30

Age (years)

Mean ± SD

42.2 ± 9.4

43.5 ± 11.2

41.6 ± 9.2

41.1 ± 6.7

0.536a)

Sex

Male

38 (38.0%)

15 (37.5%)

10 (33.3%)

13 (43.3%)

0.725b)

Female

62 (62.0%)

25 (62.5%)

20 (66.7%)

17 (56.7%)

Disease duration (years)

Mean ± SD

7.3 ± 4.8

6.9 ± 6.5

6.8 ± 3.3

8.3 ± 3.0

0.367a)

Disease type

Atopic

56 (56.0%)

19 (47.5%)

18 (60.0%)

19 (63.3%)

0.364b)

Nonatopic

44 (44.0%)

21 (52.5%)

12 (40.0%)

11 (36.7%)

Pre treatment ICS

FP/SM

40 (40.0%)

40 (100%)

0 (0%)

0 (0%)

BUD

20 (20.0%)

0 (0%)

10 (33.3%)

10 (33.3%)

FP

25 (25.0%)

0 (0%)

13 (43.3%)

12 (40.0%)

MF

15 (15.0%)

0 (0%)

7 (23.3%)

8 (26.7%)

BMI (kg/m2)

Mean ± SD

21.9 ± 2.2

22.6 ± 2.8

21.2 ± 1.9

21.5 ± 1.3

0.013a)

ACQ5 score

Mean ± SD

1.2 ± 0.42

0.81 ± 0.25

1.25 ± 0.26

1.66 ± 0.09

<0.001a)

FeNO (ppb)

Mean ± SD

43.7 ± 5.6

43.4 ± 6.8

43.4 ± 4.3

44.5 ± 4.8

0.667a)

R5-R20 (kPa/L/s)

Mean ± SD

0.093 ± 0.026

0.094 ± 0.027

0.086 ± 0.024

0.099 ± 0.026

0.141a)

Fres (Hz)

Mean ± SD

14.846 ± 2.111

14.144 ± 2.265

15.256 ± 1.928

15.373 ± 1.860

0.023a)

AX (kPa/L)

Mean ± SD

0.509 ± 0.176

0.492 ± 0.220

0.53 ± 0.151

0.512 ± 0.133

0.681a)

FEV1 (% pred)

Mean ± SD

91.53 ± 7.76

92.68 ± 8.59

92.17 ± 7.96

89.36 ± 5.99

0.182a)