|
| Overall | 2011 | 2014 | 2016 | p-value |
No. of patients |
| 100 | 40 | 30 | 30 |
|
Age (years) | Mean ± SD | 42.2 ± 9.4 | 43.5 ± 11.2 | 41.6 ± 9.2 | 41.1 ± 6.7 | 0.536a) |
Sex | Male | 38 (38.0%) | 15 (37.5%) | 10 (33.3%) | 13 (43.3%) | 0.725b) |
| Female | 62 (62.0%) | 25 (62.5%) | 20 (66.7%) | 17 (56.7%) |
|
Disease duration (years) | Mean ± SD | 7.3 ± 4.8 | 6.9 ± 6.5 | 6.8 ± 3.3 | 8.3 ± 3.0 | 0.367a) |
Disease type | Atopic | 56 (56.0%) | 19 (47.5%) | 18 (60.0%) | 19 (63.3%) | 0.364b) |
| Nonatopic | 44 (44.0%) | 21 (52.5%) | 12 (40.0%) | 11 (36.7%) |
|
Pre treatment ICS | FP/SM | 40 (40.0%) | 40 (100%) | 0 (0%) | 0 (0%) |
|
| BUD | 20 (20.0%) | 0 (0%) | 10 (33.3%) | 10 (33.3%) |
|
| FP | 25 (25.0%) | 0 (0%) | 13 (43.3%) | 12 (40.0%) |
|
| MF | 15 (15.0%) | 0 (0%) | 7 (23.3%) | 8 (26.7%) |
|
BMI (kg/m2) | Mean ± SD | 21.9 ± 2.2 | 22.6 ± 2.8 | 21.2 ± 1.9 | 21.5 ± 1.3 | 0.013a) |
ACQ5 score | Mean ± SD | 1.2 ± 0.42 | 0.81 ± 0.25 | 1.25 ± 0.26 | 1.66 ± 0.09 | <0.001a) |
FeNO (ppb) | Mean ± SD | 43.7 ± 5.6 | 43.4 ± 6.8 | 43.4 ± 4.3 | 44.5 ± 4.8 | 0.667a) |
R5-R20 (kPa/L/s) | Mean ± SD | 0.093 ± 0.026 | 0.094 ± 0.027 | 0.086 ± 0.024 | 0.099 ± 0.026 | 0.141a) |
Fres (Hz) | Mean ± SD | 14.846 ± 2.111 | 14.144 ± 2.265 | 15.256 ± 1.928 | 15.373 ± 1.860 | 0.023a) |
AX (kPa/L) | Mean ± SD | 0.509 ± 0.176 | 0.492 ± 0.220 | 0.53 ± 0.151 | 0.512 ± 0.133 | 0.681a) |
FEV1 (% pred) | Mean ± SD | 91.53 ± 7.76 | 92.68 ± 8.59 | 92.17 ± 7.96 | 89.36 ± 5.99 | 0.182a) |