Model

Purpose

Contribution

Gene Expression Profiling

Databases to measure the expression levels of genes in the non-pigmented and pigmented epithelia of the human ciliary body

Provides a comprehensive overview of gene activity in the eye’s aqueous humor production which can be adapted to study retinoblastoma

Molecular Interaction Prediction

To predict the apical interactions between non-pigmented and pigmented epithelia in silico

Sheds light on potential cellular interactions that may influence disease processes applicable to retinoblastoma gene interaction studies

Statistical Analysis for Differential Expression

To identify significant differences in gene expression between non-pigmented and pigmented epithelia

Allows for the identification of signature genes and pathways involved in eye health with potential parallels in retinoblastoma pathology