Group 1

During enrollment

1^st follow up

2^nd follow up

p-value

Six minutes’ walk distance

127.81 ± 131.44

244.6 ± 142.7

303.01 ± 125.6

<0.05^s

LVEF

30.25 ± 4.2

38.2 ± 5.7

51.0 ± 6.7

<0.05^s

LVEDD

59.30 ± 8.92

53.09 ± 6.6

46.2 ± 4.95

<0.05^s

NT-pro BNP

4536.5 ± 6198.5

4671.3 ± 4875.3

3461.08 ± 4313.9

<0.05^s

Group 2

Six minutes’ walk distance

144.36 ± 163.01

180.3 ± 135.7

212.97 ± 148.6

<0.05^s

LVEF

30.50 ± 10.26

34.7 ± 7.3

40.8 ± 7.03

<0.05^s

LVEDD

59.16 ± 11.33

58.7 ± 6.2

54.2 ± 6.2

<0.05^s

NT-pro BNP

6269.6 ± 5771.74

5619.5 ± 5671.2

5337.1 ± 5371.6

0.544^ns

Functional Class

I

II

III

IV

p-Value

1^st follow-up

Group 1

06 (5.7%)

30 (28.3%)

40 (37.7%)

30 (28.3%)

0.302^ns

Group 2

00 (0%)

22 (23.4%)

38 (40.4%)

34 (36.2%)

Functional class

2^nd follow-up

Group 1

20 (18.9%)

54 (50.9%)

22 (20.8%)

10 (9.4%)

0.001^s

Group 2

00 (0%)

08 (8.5%)

55 (58.5%)

31 (33%)