Pairwise Comparison (Time point vs. Baseline)

Time point (week)

The estimated mean difference & 95% CL

The Unadjusted p-value

1 vs. 0

1

−3.79, (−8.17, 0.59)

0.09

2 vs. 0

2

−2.5, (−8.2, 3.2)

0.39

3 vs. 0

3

−1.88, (−8.47, 4.71)

0.57

4 vs. 0

4

−3.05, (−9.41, 3.3)

0.34

5 vs. 0

5

−4.09, (−10.04, 1.85)

0.17

6 vs. 0

6

−1.92, (−8.32, 4.47)

0.55

7 vs. 0

7

−3.7, (−9.75, 2.36)

0.23

8 vs. 0

8

−7.36, (−13.68, −1.03)

0.02

9 vs. 0

9

−7.46, (−13.7, −1.22)

0.01

10 vs. 0

10

−7.92, (−14.33, −1.5)

0.01

11 vs. 0

11

−9.13, (−15.17, −3.09)

0.003