Patient Population

Effective Probiotics

Yeast

Bacteria

Meta-analyses

Goldenberg et al. 2017 [29]

Prevention of pediatric CDAD

Ÿ S. boulardii

Ÿ L. acidophilus plus L. casei

Goodman et al. 2021^a [28]

Prevention of adult AAD

Ÿ S. boulardii

Ÿ L. acidophilus

Ÿ L. bulgaricus

Ÿ L. casei

Ÿ L. paracasei

Ÿ L. rhamnosus

Ÿ Lactobacillus spp.

Ÿ B. animalis ssp. Lactis

Ÿ B. longum

Ÿ B. licheniformis

Ÿ B. subtilis

Ÿ Bac. clausii

Guo et al. 2019 [27]

Prevention of pediatric AAD

Ÿ S. boulardii

Ÿ L. rhamnosus

Systematic Review

Sniffen et al. 2018 [31]

Prevention of AAD

Ÿ S. boulardii

Ÿ L. casei DN114001

Ÿ 3-strain combination: L. acidophilus CL1285, L. casei LBC80R, and L. rhamnosus CLR2

AGA Guideline

Su 2020^b [7]

Prevention of CDAD

Ÿ S. boulardii

Ÿ 2-strain combination: L. acidophilus CL1285 and L. casei LBC80R

Ÿ 3-strain combination: L. acidophilus, L. delbrueckii subsp bulgaricus, and B. bifidum

Ÿ 4-strain combination: L. acidophilus, L. delbrueckii subsp bulgaricus, B. bifidum, and Strep. salivarius subsp thermophilus