When to switch

What to do

Target HbA1c is not achieved because of:

Ÿ Poor adherence

Switch to an OW GLP-1RA

Ÿ Disease progression or lack of efficacy of the current GLP1-RA

Switch to an agent with proven better glycemic efficacy

Ÿ The development of anti-drug antibodies

Switch to different types of GLP1-RA Switch to a human GLP-1 analogue

The need for additional weight loss

The most effective GLP1-RA is OW semaglutide. [3]

Increased CV risk in T2DM

[9] [11] [13]

Ÿ Established CVD

Dulaglutide, liraglutide or OW semaglutide

Ÿ Multiple CV risk factors


More advanced CKD status: eGFR < 30 mL/min/1.73 m2

Switch to a dulaglutide, liraglutide or OW semaglutide [9] [10] [11] [12] [63]

Adverse effects

Switch to another GLP1-RA [44]