DURATION 1 [28]

From exenatide twice daily 10 µg

To exenatide ER 2.0 mg

Further decreases in HbA1c levels of 0.2%-point.

LEAD 6 [29]

From exenatide twice daily 10 µg

To liraglutide 1.8 mg

Further decreases in HbA1c levels of 0.3%-point and weight decreased by 0.9 kg.

CIBELES Project [30]

From another GLP-1RA

To exenatide ER

Further decreases in HbA1c levels of 0.4%-point with no significant changes in weight.

Visaria et al. [31]

From another GLP-1RA

To OW semaglutide

Further decreases in HbA1c levels of 1.3%-point.

REALiSe-DM [32]

From either liraglutide or dulaglutide

To OW semaglutide

Further decreases in HbA1c levels of 0.7%-point.

The mean reduction in weight was 1.6 kg following the switch.

Watanabe et al. [33]

From exenatide twice daily

To exenatide ER

Further decreases in HbA1c levels of 0.2%-point over 24 weeks.

Incidence of hypoglycemia was also significantly reduced.

No significant changes in weight.

Goncalves and Bell study [34]

From liraglutide 1.8 mg

To OW semaglutide average dose 0.76

HbA1c decreased from 7.46% ± 1.36% to 6.68% ± 1.00%

The number of patients requiring insulin dropped from 16 to 13.

Weight dropped from 110.6 ± 20 to 106 ± 27 kg.

Overgaard et al. modeling study [35]

From another GLP-1RA

To OW semaglutide

More reductions in HbA1c

Further weigh reduction.