| DURATION 6 [20] | Reduction | Liraglutide 1.8 mg | Exenatide ER 2.0 mg |
| HbA1c | 1.5% | 1.3%-point | |
| Weight | 3.6 kg | 2.7 kg | |
| HARMONY 7 [21] | Reduction | Liraglutide 1.8 mg | Albiglutide 50 mg |
| HbA1c | 1.0% | 0.8%-point | |
| Weight | 2.2 kg | 0.6 kg | |
| LIRA–LIXI [22] | Reduction | Liraglutide 1.8 mg | Lixisenatide 20 µg |
| HbA1c | 1.8% | 1.2%-point | |
| Weight | 4.3 kg | 3.7 kg | |
| AWARD 6 [23] | Reduction | Liraglutide 1.8 mg | Dulaglutide 1.5 mg |
| HbA1c | Same |
| |
| Weight | 3.6 kg | 2.9 kg | |
| Feher et al. [24] | Reduction | Liraglutide 1.8 mg | Lixisenatide 20 µg |
| HbA1c | Mean treatment difference [95% confidence interval (CI)] −0.3%-point [−0.56; −0.04]) | ||
| SUSTAIN 3 [25] | Reduction | OW semaglutide 1.0 mg | Exenatide ER 2.0 mg |
| HbA1c | 1.5 % | 0.9% | |
| Weight | 5.6 kg | 1.9 kg | |
| SUSTAIN 7 [26] | Reduction | OW semaglutide 0.5 mg | Dulaglutide 0.75 mg |
| HbA1c | 1.5 % | 1.1% | |
| Weight | 4.6 kg | 2.3 kg | |
|
| OW semaglutide 1 mg | Dulaglutide 1.5 mg | |
| HbA1c | 1.8% | 1.4% | |
| Weight | 6.5 kg | 3 kg | |
| SUSTAIN 10 [27] | Reduction | OW semaglutide 1.0 mg | Liraglutide 1.2 mg |
| HbA1c | 1.7% | 1.0% | |
| Weight | 5.8 kg | 1.9 kg | |