Author, Year | Type of Surgery | Method of Mg administration | Rate of Mg infusion | Intraoperative (I) or Postoperative (P) | # of Subjects (#Mg/#Control) | Control | Cumulative |Morphine Consumption within first 24 hours (Magnesium group) (mg) | Cumulative Morphine Consumption with first 24 hours (Control group) (mg) |
Wilder- Smith, 1997 [35] | Abdominal hysterectomy | Bolus + continuous infusion | 200 mg/h | I, P | 13/11 | Placebo | 41.8 ± 9.6 | 46.8 ± 14.1 |
Zarauza, 2000 [36] | Colorectal surgery | Bolus + continuous infusion | 10 mg/kg/h | I, P | 23/24 | Placebo and saline | 39.8 ± 9.2 | 46.6 ± 11.3 |
Kara, 2002 [37] | Abdominal hysterectomy | Bolus + continuous infusion | 500 mg/h | I, P | 12/12 | Saline | 35.55 ± 0.48 | 43.43 ± 7.2 |
Levaux, 2003 [38] | Orthopedic surgery | Continuous infusion | 50 mg/kg/ 30 mins | I | 12/12 | Saline | 42.37 ± 17.75 | 68.8 ± 26.51 |
Bhatia, 2004 [39] | Open cholecystectomy | Bolus + continuous infusion | 10 mg/kg/h | I | 25/25 | Saline | 13.7 ± 3 | 15.2 ± 2.7 |
Seyhan, 2006 (1) [40] | Abdominal hysterectomy | Bolus | 40 mg/kg/h | I, P | 20/20 | Saline | 42.2 ± 16.4 | 64 ± 10.2 |
Seyhan, 2006 (2) [40] | Abdominal hysterectomy | Bolus + continuous infusion | 10 mg/kg/h | I, P | 20/20 | Saline | 39.2 ± 15.5 | 64 ± 10.2 |
Seyhan, 2006 (3) [40] | Abdominal hysterectomy | Bolus + continuous infusion | 20 mg/kg/h | I, P | 20/20 | Saline | 39.16 ± 15.51 | 64 ± 10.2 |
Tauzin-fin, 2006 [41] | Prostatectomy | Continuous infusion | 16.7 mg/kg/h | I | 15/15 | Saline | 226 ± 60 | 444 ± 73 |
Ozcan, 2007 [42] | Thoracotomy | Bolus + continuous infusion | 10 mg/kg/h | P | 12/12 | Saline | 22.2 ± 3.8 | 23.5 ± 4.6 |
O-mentes, 2008 [43] | Laparoscopic cholecystectomy | Continuous infusion only | n/a | I | 41/42 | Saline | 12 ± 6.4 | 23 ± 11.5 |
Ferasatkish, 2008 [44] | Coronary artery bypass surgery | Continuous infusion only | 32 nmol/kg/h | I | 109/109 | Saline | 13.6 ± 2.8 | 20.1 ± 3.5 |
Oguzhan, 2008 [45] | Lumbar disc surgery | Continuous infusion only | 10 mg/kg/h | I | 25/25 | Saline | 56.27 ± 18.16 | 63.49 ± 25.92 |
Kaya, 2009 [46] | Abdominal hysterectomy | Bolus + continuous infusion | 500 mg/h | I | 20/20 | Saline | 30.2 ± 10.2 | 36.7 ± 7.3 |
Dabbagh, 2009 [47] | Lower limb surgery | Continuous infusion only | 8 mg/kg/h | I | 30/30 | Saline | 4.2 ± 1.6 | 9.8 ± 1.2 |
Saadawy, 2010 [48] | Laparoscopic cholecystectomy | Bolus + continuous infusion | 25 mg/kg/h | I | 40/40 | Saline | 16.1 ± 8.6 | 27.2 ± 9.3 |
Kumar, 2013 [20] | Below umbilical surgeries | Bolus + continuous infusion | 10 mg/kg/h | I | 30/30 | Saline | 3.99 ± 1.25 | 7.13 ± 2.68 |