Genotypes

Levels with disc degeneration

0 (n = 58)

n (%)

1 (n = 47)

n (%)

2 (n = 31)

n (%)

≥3 (n = 33)

n (%)

P

Adjusted

p value

VDR Fok1

FF

48 (82.7)

30 (63.8)

10 (32.2)

7 (21.2)

Ff

9 (15.5)

13 (27.7)

15 (48.4)

18 (54.5)

0.002*

0.01*

ff

1 (1.8)

4 (8.5)

6 (19.4)

8 (24.3)

Dominant model

FF + Ff

57 (98.2)

43 (91.5)

25 (80.6)

25 (75.7)

ff

1 (1.8)

4 (8.5)

6 (19.4)

8 (24.3)

<0.001*

0.004*

Recessive model

FF

48 (82.7)

30 (63.8)

10 (32.2)

7 (21.2)

Ff + ff

10 (17.3)

17 (36.2)

23 (67.8)

26 (78.8)

<0.001*

0.006*

F allele

105 (90.5)

73 (77.6)

35 (56.4)

32 (48.4)

f allele

11 (9.5)

21 (22.4)

27 (43.6)

34 (51.5)

0.001*

0.005*

Vit D (ng/ml)

(mean ± SD)

25.4 ± 4.2

22.3 ± 5.6

20.3 ± 5.8

19.5 ± 4.9

0.024*

(mean ± SD)

0.028*

VDR mRNA level

(mean ± SD)

3.9 ± 0.5

2. 8 ± 0.7

2.0 ± 0.61

1.7 ± 0.8

0.031*

0.042*