Genotypes/alleles

Healthy Controls (n = 169) n (%)

LDD patients

(n = 169) n (%)

OR (95% CI)

P

Adjusted

OR (95% CI)

Adjusted p value

VDR Fok1

FF

121 (71.6)

95 (56.2)

Ff

45 (26.6)

55 (32.5)

1.53 (0.98 - 2.80)

0.15

1.32 (0.67 - 2.64)

0.32

ff

3 (1.8)

19 (11.3)

8.7 (2.5 - 29.9)

0.003*

7.9 (2.3 - 26.6)

0.01*

Dominant model

FF + Ff

166 (98.2)

150 (88.7)

ff

3 (1.8)

19 (11.3)

6.0 (1.3 - 28)

0.018*

5.8 (1.2 - 26.4)

0.023*

Recessive model

FF

121 (71.6)

95 (56.2)

Ff + ff

48 (28.4)

74 (43.8)

2.0 (1.1 - 3.6)

0.027*

2.4 (1.0 - 3.5)

0.033*

F allele

287 (84.9)

245 (72.5)

f allele

51 (15.1)

93 (27.5)

2.3 (1.54 - 3.21)

0.023*

2.2 (1.6 - 3.7)

0.031*

Vitamin D (ng/ml)

(mean ± SD)

36 ± 7.1

21.6 ± 5.3

<0.001*

0.003*

VDR mRNA level

(mean ± SD)

3.63 ± 0.61

2.98 ± 0.8

0.007*

0.009*